May 2017: The Clear group receives an MSU CISR grant
February 2017: The Clear group receives the 2017 Marshall and Annette Gordon chemistry research grant
Research in the Clear Lab integrates themes from organic, physical, and analytical chemistry to address questions regarding recognition of biologically important anions. The emphasis of projects currently underway in the group is on the development of synthetic receptors for solution and membrane recognition of inositol phosphates and phosphatidylinositide lipids, a class of molecues that are important for cell communication. The results of this research will contribute to the scientific knowledge that will be both directly and indirectly beneficial to biological or biochemical separations, understanding of signaling pathways and lipid dynamics, molecular imaging, and therapeutic applications. Importantly, students participating in research will be exposed to a range of techniques, from traditional organic synthesis to binding studies requiring repetitive measurement and extensive data analysis. As a result, this research experience will help train students for graduate and professional studies as well as careers in industry.
Dr. Clear is a native of Niles, Michigan and was awarded his B.S. in Chemistry from Indiana University South Bend in 2011. He completed his Ph.D. in 2016 at the University of Notre Dame under the supervision of Professor Bradley D. Smith, where he studied anion and biomembrane molecular recognition using synthetic receptors and fluorescent dyes. As a graduate student, Dr. Clear co-authored six peer-reviewed articles and one book chapter. He began his independent career in academia at Murray State University in fall of 2016. His research interests include the design and study of synthetic receptors for biologically important anions that will have application in separations, imaging, and chemical biology.
Dr. Clear primarily teaches organic chemistry at both the undergraduate and graduate level. He is currently teaching or has taught the following courses at MSU:
CHE 210 - Brief Organic Chemistry
CHE 215 - Brief Organic Chemistry Laboratory
CHE 320 - Organic Chemisty II
CHE 325 - Organic Chemistry II Laboratory
CHE 517/617 - Advanced Organic Chemistry
In addition, Dr. Clear is the seminar coordinator for the chemistry department (CHE 601/602).
Department of Chemistry
Murray State University
1232 Jesse D. Jones Hall (office, lab is room 1233)
Office phone: (270) 809-6597 (office phone)
BSA Vet Tech/Animal Tech
Jacob Meadows, B.S. Chemistry
Motivated undergraduate and graduate students who are interested in doing research are welcome to join. If you are interested, contact Dr. Clear by e-mail (email@example.com) or just stop by his office (1232 CB).
7. Harmatys, K. M., Musso, A. J., Clear, K. J., Smith, B. D. (2016) Small molecule additive enhances cell uptake of 5-aminolevulinic acid and conversion to protoporphyrin IX. Photochem. Photobiol. Sci. Advance Article, DOI: 10.1039/C6PP00151C Link
6. Rice, D. R., Clear, K. J., Smith, B. D. (2016) Imaging and therapeutic applications of zinc(ii)-dipicolylamine molecular probes for anionic biomembranes. Chem. Commun. 52, 8787-8801 Link
5. Clear, K. J., Virga, K., Gray, L., and Smith, B. D. (2016) Using membrane composition to fine-tune the pKa of an optical liposome pH sensor. J. Mater. Chem. C 4, 2925-2930 Link
4. Clear, K. J., Harmatys, K. M., Rice, D. R., Wolter, W. R., Suckow, M. A., Wang, Y., Rusckowski, M., and Smith, B. D. (2016) Phenoxide-bridged zinc(II)-bis(dipicolylamine) probes for molecular imaging of cell death. Bioconjugate Chem. 27, 363-375 Link
3. Clear, K. J. and Smith, B. D. (2015) Synthetic Receptors for Polar Lipids. Synthetic Receptors for Biomolecules, Monographs in Supramolecular Chemistry, Royal Society of Chemistry: pp 405-436 Link
2. Plaunt, A. J., Clear, K. J., and Smith, B. D. (2014) 19F NMR indicator displacement assay using a synthetic receptor with appended paramagnetic relaxation agent. Chem. Commun. 50, 10499-10501 Link
1. Clear, K. J., Stroud, S., and Smith, B. D. (2013) Dual colorimetric and luminescent assay for dipicolinate, a biomarker of bacterial spores. Analyst 138, 7079-7082 Link
Photos coming soon!